- Ctrl-L brings you to the URL bar. Think of all the time you'll save not having to move your hand from mouse to keyboard everytime you want to go to a new website.
- You can 'train' Chrome to remember how to search a website. As an example, go to Amazon and do an empty search. Then, when typing amazon into the url bar you can press tab and enter a search that will be performed on amazon. I find this really useful for browsing Wikipedia.